Department ofPhysics of Complex Systems
Biological Complexity

Prof. Elisha Moses

Treating living neuronal cultures as physical systems—and asking whether they can be wired into logic

01 / Research

Research

The group studies neuronal networks as physical systems, using cultures of dissociated neurons grown on multi-electrode arrays and patterned substrates to ask how computation and collective dynamics emerge from many coupled excitable cells. By shaping connectivity, stimulating subpopulations, and reading out spiking activity, the lab probes how a culture integrates inputs, propagates activity bursts, and can be coaxed into performing elementary logical operations—effectively asking what it takes to build a device from living neural tissue.

A second thread develops physical tools to stimulate and observe neural activity, combining magnetic stimulation with optical and electrical measurement of the response. Because magnetic fields penetrate tissue with minimal attenuation, understanding how induced currents excite neurons connects directly to the physics of transcranial magnetic stimulation and to noninvasive readout of brain dynamics. Together these lines treat the nervous system as a substrate whose excitability, geometry, and noise set the rules for both natural function and engineered behavior.

Multi-electrode arraysPatterned neuronal culturesMagnetic stimulationCalcium and voltage imagingSpike-train analysisNetwork modeling
Logic from neuronal culturesEngineering patterned cultures whose evoked activity implements thresholding and elementary logical operations as a step toward biological computing devices.
Magnetic stimulation of neuronsQuantifying how induced electric fields excite neurons to ground transcranial magnetic stimulation in cellular biophysics.
Optical readout of activityUsing calcium and voltage imaging to map network-wide responses to controlled stimulation in real time.
Bursts and network dynamicsCharacterizing the spontaneous synchronization, propagation fronts, and excitability that govern collective activity in cultured networks.
Connectivity and geometryShaping substrate topology to test how wiring constraints determine signal flow and computational capacity.
02 / People

Group members

Principal investigatorProf. Elisha Moses
Early-career scientistsPostdoctoral researchers
Doctoral researchersPhD students
Master's researchersMSc students

The named roster for each group is generated from the People directory, filtered by this group.

03 / Output

Selected publications

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Design