Department ofPhysics of Complex Systems
Biological Complexity

Prof. Ariel Amir

Reading the quantitative laws of growing, dividing cells through the lens of statistical physics

01 / Research

Research

The group develops physical theory for living systems, asking how the noisy, microscopic behavior of cells and molecules gives rise to robust, quantitative regularities at the level of the whole organism. A central theme is cell growth and size control: why bacteria and other cells maintain remarkably tight distributions of size, shape, and cycle timing despite stochastic gene expression and noisy division. By treating these as problems in statistical physics, the work seeks coarse-grained laws and mechanisms that hold across organisms rather than system-specific descriptions.

More broadly, the group studies how disorder, fluctuations, and feedback shape biological structure and dynamics, from the mechanics and morphogenesis of cell walls to the statistics of mutation accumulation, aging, and population growth. The same toolkit reaches into condensed-matter and disordered systems, where questions about glassy relaxation, localization, and random matrices connect to the broader physics of complex systems. The aim is explanatory theory: minimal models, tested against quantitative single-cell and population data, that reveal the principles underlying biological order.

Stochastic processesStatistical mechanicsCoarse-grained modelingSingle-cell data analysisRandom matrix theoryContinuum mechanics
Cell size homeostasisStochastic models of growth and division that explain how cells correct size fluctuations and converge to narrow size distributions.
Single-cell growth dynamicsQuantitative description of exponential versus linear growth and the coupling between growth rate, cell cycle, and gene expression noise.
Cell shape and morphogenesisPhysics of cell-wall mechanics and surface growth that set the size, shape, and curvature of bacterial and other cells.
Mutations, aging, and populationsStatistical theory of mutation accumulation, lineage variability, and how single-cell noise propagates into population-level growth and senescence.
Disordered and glassy systemsRandom-matrix and statistical-physics approaches to relaxation, localization, and slow dynamics in disordered media.
02 / People

Group members

Principal investigatorProf. Ariel Amir
Early-career scientistsPostdoctoral researchers
Doctoral researchersPhD students
Master's researchersMSc students

The named roster for each group is generated from the People directory, filtered by this group.

03 / Output

Selected publications

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Design